{"id":2805,"date":"2026-02-20T12:08:09","date_gmt":"2026-02-20T11:08:09","guid":{"rendered":"https:\/\/ptb-rug.com\/?p=2805"},"modified":"2026-02-20T12:08:21","modified_gmt":"2026-02-20T11:08:21","slug":"dr-marina-trombetta-lima","status":"publish","type":"post","link":"https:\/\/ptb-rug.com\/?p=2805","title":{"rendered":"Dr. Marina Trombetta Lima"},"content":{"rendered":"<div class=\"elementor-element elementor-element-58d77b1 e-con-full e-flex e-con e-child\" data-id=\"58d77b1\" data-element_type=\"container\" data-e-type=\"container\">\n<div class=\"elementor-element elementor-element-da02b45 elementor-widget elementor-widget-text-editor\" data-id=\"da02b45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">\n<div><b>Advanced Human Models<\/b><\/div>\n<div>\n<p>The\u00a0<b>Matrix Organoid Lab<\/b>\u00a0is led by Dr Marina Trombetta-Lima and explores microenvironment engineering as a new conceptual and technological framework to decode aging and different human diseases.<\/p>\n<p>We work with the postulate that aging and metabolic disorders do not arise from isolated organ dysfunction, but from disrupted inter-organ communication embedded within evolving tissue microenvironments. To test this paradigm, we develop next-generation human organoid-based platforms that reconstruct endocrine, inflammatory, and metabolic signaling across organs. Our disease models focus on mechanistic reconstruction allowing precision intervention.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-d99028a e-con-full e-flex e-con e-child\" data-id=\"d99028a\" data-element_type=\"container\" data-e-type=\"container\">\n<div class=\"elementor-element elementor-element-afb57f6 e-con-full e-flex e-con e-child\" data-id=\"afb57f6\" data-element_type=\"container\" data-e-type=\"container\">\n<div class=\"elementor-element elementor-element-2ebea40 elementor-widget elementor-widget-text-editor\" data-id=\"2ebea40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">\n<p><strong>Core pillars:<\/strong><\/p>\n<ul>\n<li>Microenvironment engineering as a unifying disease principle<\/li>\n<li>Human multi-organ organoid systems with controlled inter-organ signaling<\/li>\n<li>Systems-level dissection of endocrine\u2013immune\u2013neural crosstalk<\/li>\n<li>Translation toward stratified, mechanism-based therapeutic strategies<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Advanced Human Models The\u00a0Matrix Organoid Lab\u00a0is led by Dr Marina Trombetta-Lima and explores microenvironment engineering as a new conceptual and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1008,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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