{"id":3656,"date":"2026-02-28T15:23:30","date_gmt":"2026-02-28T14:23:30","guid":{"rendered":"https:\/\/ptb-rug.com\/?p=3656"},"modified":"2026-03-02T16:22:34","modified_gmt":"2026-03-02T15:22:34","slug":"lei-liang","status":"publish","type":"post","link":"https:\/\/ptb-rug.com\/?p=3656","title":{"rendered":"Lei Liang"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3656\" class=\"elementor elementor-3656\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4823e6f7 e-flex e-con-boxed e-con e-parent\" data-id=\"4823e6f7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4f3ae1c0 e-con-full e-flex e-con e-child\" data-id=\"4f3ae1c0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4cb5249 e-con-full e-flex e-con e-child\" data-id=\"4cb5249\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-32156def elementor-widget elementor-widget-image\" data-id=\"32156def\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"420\" height=\"600\" src=\"https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img-420x600.jpg\" class=\"attachment-medium size-medium wp-image-3744\" alt=\"Lei Liang PhD student\" srcset=\"https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img-420x600.jpg 420w, https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img-105x150.jpg 105w, https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img-17x24.jpg 17w, https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img-25x36.jpg 25w, https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img-34x48.jpg 34w, https:\/\/ptb-rug.com\/wp-content\/uploads\/2026\/02\/lian-img.jpg 448w\" sizes=\"(max-width: 420px) 100vw, 420px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5215b77f e-con-full e-flex e-con e-child\" data-id=\"5215b77f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-71df4a5a elementor-widget elementor-widget-heading\" data-id=\"71df4a5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Lei Liang<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e82a212 elementor-widget elementor-widget-heading\" data-id=\"e82a212\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Postdoctoral researcher<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c13fd49 elementor-widget elementor-widget-text-editor\" data-id=\"5c13fd49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div><div class=\"rug-layout rug-mb-xs\"><h5><a class=\"rug-link--undecorated\" href=\"https:\/\/www.rug.nl\/staff\/departments\/10808\">Faculty of Science and Engineering<\/a><\/h5><h5 class=\"rug-layout__item rug-width-m-6-24 rug-attributes__label overflow-wrap-normal\"><strong>Telephone:<\/strong><\/h5><\/div><\/div><div class=\"rug-layout rug-mb-m\"><h5 class=\"rug-layout__item rug-width-m-6-24 rug-attributes__label\"><strong>E-mail:<\/strong><\/h5><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ffd6a89 e-flex e-con-boxed e-con e-parent\" data-id=\"7ffd6a89\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6ffe0f53 e-con-full e-flex e-con e-child\" data-id=\"6ffe0f53\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f76d72c elementor-widget elementor-widget-text-editor\" data-id=\"1f76d72c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5><strong>Applying Pharmacometabolomics to Assess Large-Molecule Drug Effects in Human Placental Slices<\/strong><\/h5><p>Background<\/p><p>This project investigates how therapeutic antibodies, such as trastuzumab, interact with the human placenta during pregnancy. While these biologic medicines are increasingly prescribed to women of reproductive age, their effects on placental function and fetal safety remain insufficiently understood.<\/p><p>Tool:<\/p><p>To characterize the metabolic response of human placental tissue to the therapeutic monoclonal antibody Trastuzumab, using ex vivo placental slices combined with LC\u2013HRMS pharmacometabolomics (PMx).<\/p><p>Aim<\/p><p>Using human placental tissue models combined with advanced metabolomics technologies, this study aims to detect subtle functional changes in placental metabolism that may not be visible through traditional genetic or molecular analyses. By focusing on metabolic pathways related to inflammation, oxidative stress, and energy balance, the project provides a systems-level view of how the placenta responds to antibody exposure.<\/p><p>Innovative\/Influence<\/p><p>The innovative aspect of this work lies in applying metabolomics to placental research on biologic therapies, offering a new way to assess drug safety at the maternal\u2013fetal interface. The findings are expected to contribute to improved risk assessment of medication use during pregnancy and to support safer, evidence-based treatment decisions for pregnant women.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c692f15 e-flex e-con-boxed e-con e-parent\" data-id=\"c692f15\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-01e718b e-con-full e-flex e-con e-child\" data-id=\"01e718b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-906ab15 elementor-widget elementor-widget-text-editor\" data-id=\"906ab15\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"rug-mb-m\"><h4>Research Output<\/h4><div>\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e7c3fd elementor-widget elementor-widget-shortcode\" data-id=\"7e7c3fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\r\n        <div id=\"orcid-container\">\r\n            <ul class=\"orcid-list\"><\/ul>\r\n            <button id=\"orcid-load-more\">Load 20 more publications<\/button>\r\n        <\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Lei Liang Postdoctoral researcher Faculty of Science and Engineering Telephone: E-mail: Applying Pharmacometabolomics to Assess Large-Molecule Drug Effects in Human [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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[&hellip;]","_links":{"self":[{"href":"https:\/\/ptb-rug.com\/index.php?rest_route=\/wp\/v2\/posts\/3656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ptb-rug.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ptb-rug.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ptb-rug.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ptb-rug.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3656"}],"version-history":[{"count":16,"href":"https:\/\/ptb-rug.com\/index.php?rest_route=\/wp\/v2\/posts\/3656\/revisions"}],"predecessor-version":[{"id":3751,"href":"https:\/\/ptb-rug.com\/index.php?rest_route=\/wp\/v2\/posts\/3656\/revisions\/3751"}],"wp:attachment":[{"href":"https:\/\/ptb-rug.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ptb-rug.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ptb-rug.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}