Publications – Department of Pharmaceutical Technology and Biopharmacy

See Past Publications – Department of Pharmaceutical Technology and Biopharmacy

2026

Clinical utility of blood-based biomarkers in pregnant women with inflammatory bowel disease.

Holstein HJ, Bouwknegt DG, Gordijn SJ, Dijkstra G, Cantineau AEP, Mian P, van Goor H, Visschedijk MC, Bourgonje AR — DOI: 10.1080/14737159.2026.2661745

Simulation of Imatinib Pharmacokinetics in pregnant women with chronic myeloid leukemia in the third trimester.

Mian P, Lok CAR, Dontje AEWK, Prins JR, Oude Munnink TH, Nieuwenhuizen L, Gordijn SJ, Touw DJ, Malik P — DOI: 10.1007/s00228-026-04049-z

Cryomilling of freeze dried low-Tg sugar glasses: A versatile method to prepare inhalable dry powder formulations.

Jansen EM, Posthumus SAE, Chan MKT, Beertema M, Mulia KF, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.ejpb.2026.115065

Generation and viability evaluation of human precision-cut placental slices for ex vivo studies.

Wang H, Pierik E, Schoots M, Wijmans C, Hammond J, Elzinga F, Vos M, Gordijn S, Touw D, Prins JR, Olinga P, Mian P — DOI: 10.1016/j.placenta.2026.03.008

Regenerative therapeutics for chronic obstructive pulmonary disease.

van der Koog L, Showell HRD, Nugraha DF, Lehmann M, Conlon TM, Yildirim AÖ, Fuentes-Mateos R, Baarsma H, Ng-Blichfeldt JP, Melgert BN, Dost AFM, Burgess JK, Yam SLS, Heijink IH, Ahmed S, Paschini M, Jansen EM, Hinrichs WLJ, Johnson JR, Wu X, Nagelkerke A, Frijlink HW, Kim CF, Gosens R — DOI: 10.1016/j.pharmr.2026.100124

Receptor agonist of NFκB signaling ligand directs lung epithelial cell expansion through RANK signaling.

Habibie H, Vlasma JR, Putri KSS, Song S, de Jager MH, Petersen A, Boorsma CE, Cool RH, Quax W, Nawijn MC, Timens W, Burgess JK, Brandsma CA, Melgert BN — DOI: 10.1152/ajplung.00176.2025

Freeze-Drying in Sucrose Followed by Cryomilling Enables the Formulation of sa-mRNA-LNP Powders for Inhalation.

Jansen EM, Ruigrok MJR, Suh MS, Ruppel PM, Cui X, Opsomer L, Sanders NN, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics18010121

Inter-species variability in 4,4'-methylenedianiline metabolism: insights from human and rat precision-cut liverslices.

Hof MAJ, Sewdihal J, Stepanovic S, Hermans JH, Horvatovich P, Olinga P, Klont F — DOI: 10.1016/j.yrtph.2026.106034

Gradient in Motion: Mechanical Stimulation Of Cells Cultured on Melt Electrowritten Scaffolds.

Zieliński PS, Gudeti PKR, Koch M, Olinga P, Kamperman M, Włodarczyk-Biegun MK — DOI: 10.1016/j.actbio.2025.12.053

Identification of Subtype-Specific Vulnerabilities in Resistant Glioblastoma: A Computational Pipeline for Biomarkers and Drug Discovery.

Lopez-Parra JS, Hameedat F, Sousa SF, Walenkamp AME, Sousa F, A Santos H — DOI: 10.1021/acs.molpharmaceut.5c01538

Osteoprotegerin Is Elevated in Pulmonary Fibrosis and Associates with Idiopathic Pulmonary Fibrosis Progression: A Pilot Study.

Habibie H, Putri KSS, Boorsma CE, Brass DM, Heukels P, Wijsenbeek M, Kool M, van den Berge M, Borghuis T, Vaughan A, Corte T, Liu G, Brandsma CA, Gan CT, Olinga P, Timens W, Kahn N, Hansbro PM, Kreuter M, Burgess JK, Melgert BN — DOI: 10.1159/000547439

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development.

Jansen EM, van der Koog L, Elferink RAB, Rafie K, Nagelkerke A, Gosens R, Frijlink HW, Hinrichs WLJ — DOI: 10.1002/smll.202411096

2025

Extracellular Vesicle-Mediated Delivery of Antioxidant Enzymes: Emerging Insights and Translational Opportunities.

Wang J, Li Y, Dullaart RPF, Olinga P, Moshage H — DOI: 10.3390/antiox14121504

Identification of Subtype-Specific Vulnerabilities in Resistant Glioblastoma: A Computational Pipeline for Biomarkers and Drug Discovery.

Lopez-Parra JS, Hameedat F, Sousa SF, Walenkamp AME, Sousa F, A Santos H — DOI: 10.1021/acs.molpharmaceut.5c01538

Leucine Protects Dry Powders for Inhalation Against Irreversible Moisture-Induced Aggregation.

Jansen EM, van der Koog L, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics17111391

Differential stress responses of immunoisolated human islets embedded in pancreatic extracellular matrix under static and free-fall dynamic conditions.

Borges-Silva I, Mantovani MDC, Danh Anh Luu M, Gorter A, Borghuis T, Gasaly N, Cleide Sogayar M, deVos P, Trombetta-Lima M — DOI: 10.1177/20417314251383295

The Potential of L. (Thyme) Essential Oil Coating in Preventing Vulvovaginal Candidiasis on Intrauterine Device (IUD) Strings.

Sahal G, Donmez HG, Woerdenbag HJ, Taner A, Beksac MS — DOI: 10.3390/pharmaceutics17101304

Understanding the impact of excipient variability on oral solid dosage form performance: A possible role for multivariate data analysis, in the form of principal component analysis.

Janssen PHM, Dickhoff BHJ, Ferreira A, Gamble J, Shinebaum R, Tobyn M — DOI: 10.1016/j.xphs.2025.104021

Placental slice techniques in physiology, pathophysiology, and toxicology: A systematic review with a focus on precision-cut slices.

Wang H, Elzinga FA, Nagelkerke A, Touw DJ, Rozendaal F, Hillawie LA, Haan D, Brook B, Gordijn SJ, Prins JR, Olinga P, Mian P — DOI: 10.1016/j.placenta.2025.09.022

An In Vitro-In Vivo Comparison of Two Levodopa Dry Powder Products for Inhalation: A Randomized Trial Comparing Inbrija and Levodopa Cyclops.

Berends JME, Wimmenhove EJ, Hoppentocht M, Hagedoorn P, Frijlink HW, Grasmeijer F — DOI: 10.3390/pharmaceutics17091149

Safety Considerations for Natural Products with Adaptogenic and Immunomodulating Activities.

Liang CJW, Woerdenbag HJ, Ekhart C, Vitalone A, van Hunsel FPAM — DOI: 10.3390/ph18081208

Extemporaneous Compounding, Pharmacy Preparations and Related Product Care in the Netherlands.

Woerdenbag HJ, van Basten B, Oussoren C, Smeets OSNM, Annaciri-Donkers A, Crul M, Maurer JM, Schimmel KJM, Kemper EM, Hooge MNL, Schreuder N, Eikmann M, Ramcharan AS, Lantink RB, Quodbach J, Boersma HH, Kelder O, Larmené-Beld KHM, Le Brun PPH, Kok RJ, Schellekens RCA, Breukels O, Frijlink HW, Gareb B — DOI: 10.3390/pharmaceutics17081005

Pre-stimulation of precision-cut bovine udder slices with zymosan before LPS exposure indicates aspects of trained immunity especially in the absence of FCS.

Filor V, Myslinska J, Saliani A, Dalli J, Olinga P, Bäumer W, Werling D — DOI: 10.1177/17534259251360484

Osteoprotegerin Is Elevated in Pulmonary Fibrosis and Associates with Idiopathic Pulmonary Fibrosis Progression: A Pilot Study.

Corrigendum to "Development of a stable inhalable dry powder formulation with osteoglycin fragment for alveolar epithelial repair" [Int. J. Pharm. 682 (2025) 125913].

van der Koog L, Jansen EM, Elferink RAB, Bos SIT, Nagelkerke A, Gosens R, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.ijpharm.2025.125968

Development of a stable inhalable dry powder formulation with osteoglycin fragment for alveolar epithelial repair.

van der Koog L, Jansen EM, Elferink RAB, Bos SIT, Nagelkerke A, Gosens R, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.ijpharm.2025.125913

Quantifying cross-linking strength in sodium starch glycolate and its impact on tablet disintegration and dissolution.

Janssen PHM, Rijpkema W, Stout K, Orbons M, Patel A, Dickhoff BHJ — DOI: 10.1016/j.ejpb.2025.114803

The cannabinoid CB receptor: improvement of sleep or memory in rotenone model of Parkinson's disease.

Targa ADS, Dos Santos-Lima GZ, Rodrigues LS, Cavalcante SF, Fontenele-Araújo J, Torterolo P, Fagotti J, Ilkiw J, Noseda ACD, Trombetta-Lima M, Dorieux F, Dominico PS, Sogayar MC, Andersen ML, Stern CA, Lima MMS — DOI: 10.1016/j.ejphar.2025.177745

Correction: van den Born-Bondt et al. Development of an Adaptable Qualification Test Set for Personnel Involved in Visual Inspection Procedures of Parenteral Drug Products Manufactured Under Good Manufacturing Practice Conditions in Hospital Pharmacy Compounding Facilities. 2025, , 74.

van den Born-Bondt T, Huizinga HPS, Kappert KR, Westra HH, van Zanten J, Woerdenbag HJ, Maurer JM, Gareb B — DOI: 10.3390/pharmaceutics17050564

Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers.

Thorne AM, Geng Y, Lantinga VA, Smit M, Kuivenhoven JA, Porte RJ, Kuipers F, Olinga P, Wolters JC, de Meijer VE — DOI: 10.14814/phy2.70348

Characterization of Extracellular Vesicles Derived From Human Precision-Cut Liver Slices in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Geng Y, Luo K, Stam J, Oosterhuis D, Gorter AR, van den Heuvel M, Crescitelli R, de Meijer VE, Wolters JC, Olinga P — DOI: 10.1002/jex2.70043

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.

Peters L, Rakateli L, Huchzermeier R, Bonnin-Marquez A, Maas SL, Lin C, Jans A, Geng Y, Gorter A, Gijbels M, Rensen S, Olinga P, Hendrikx T, Krawczyk M, Brisbois M, Jankowski J, Bidzhekov K, Weber C, Biessen EAL, Shiri-Sverdlov R, Houben T, Döring Y, Bartneck M, van der Vorst E — DOI: 10.7554/eLife.97165

Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin in Children with Cystic Fibrosis.

Akkerman-Nijland AM, Hagedoorn P, Rottier BL, Grasmeijer F, Frijlink HEW, van Luin M, Ter Weijden E, Merkus PJ, Touw DJ, Akkerman OW, Koppelman GH — DOI: 10.3390/pharmaceutics17030347

Mechanotransduction and Skeletal Muscle Atrophy: The Interplay Between Focal Adhesions and Oxidative Stress.

Kamal KY, Trombetta-Lima M — DOI: 10.3390/ijms26062802

Fibroblast-derived osteoglycin promotes epithelial cell repair.

van der Koog L, Woest ME, Gorter IC, Verschut V, Elferink RAB, Zuidhof AB, Nugraha DF, Koloko Ngassie ML, Bos SIT, Dhakad D, Wolters JC, Horvatovich PL, Prakash YS, Timens W, Yildirim ÖA, Brandsma CA, Frijlink HW, Nagelkerke A, Gosens R — DOI: 10.1038/s41536-025-00404-3

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development.

Jansen EM, van der Koog L, Elferink RAB, Rafie K, Nagelkerke A, Gosens R, Frijlink HW, Hinrichs WLJ — DOI: 10.1002/smll.202411096

Azithromycin as Host-Directed Therapy for Pulmonary Tuberculosis: A Randomized Pilot Trial.

Dekkers BGJ, Kerstjens HAM, Breisnes HW, Leeming DJ, Anthony RM, Frijlink HW, van der Werf TS, Kosterink JGW, Alffenaar JC, Akkerman OW — DOI: 10.1093/infdis/jiaf069

What Is the Optimal Geometry of Dissolving Microneedle Arrays? A Literature Review.

Visscher M, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics17010124

Development of an Adaptable Qualification Test Set for Personnel Involved in Visual Inspection Procedures of Parenteral Drug Products Manufactured Under Good Manufacturing Practice Conditions in Hospital Pharmacy Compounding Facilities.

van den Born-Bondt T, Huizinga HPS, Kappert KR, Westra HH, van Zanten J, Woerdenbag HJ, Maurer JM, Gareb B — DOI: 10.3390/pharmaceutics17010074

Studying the intracellular bile acid concentration and toxicity in drug-induced cholestasis: Comprehensive LC-MS/MS analysis with human liver slices.

Karsten REH, Gier K, de Meijer VE, Huibers WHC, Permentier HP, Verpoorte E, Olinga P — DOI: 10.1016/j.tiv.2025.106011

Taylor dispersion analysis and release studies of β-carotene-loaded PLGA nanoparticles and liposomes in simulated gastrointestinal fluids.

Fortunatus RM, Balog S, Sousa F, Vanhecke D, Rothen-Rutishauser B, Taladriz-Blanco P, Petri-Fink A — DOI: 10.1039/d4ra08138b

Personalized parathyroid hormone therapy for hypoparathyroidism: Insights from pharmacokinetic-pharmacodynamic modelling.

Visscher M, Schuls-Fouchier M, Berends AMA, Muller Kobold AC, Punt NC, Touw DJ — DOI: 10.1111/bcp.16342

Qualitative Interviews with Stakeholders in Herbal Pharmacovigilance and Recommendations for Best Practices to be Applied Worldwide.

Ekhart C, Wiarda SHP, van de Koppel S, Skalli S, Alghamdi W, Menniti-Ippolito F, Tangchitkhachon K, Mponda JS, Woerdenbag HJ, van Hunsel F — DOI: 10.1007/s40264-024-01480-y

The environmental burden of inhalation.

de Boer AH — DOI: 10.1016/j.ejps.2024.106893

Previous Years

2024

Personalized parathyroid hormone therapy for hypoparathyroidism: Insights from pharmacokinetic-pharmacodynamic modelling.

Visscher M, Schuls-Fouchier M, Berends AMA, Muller Kobold AC, Punt NC, Touw DJ — DOI: 10.1111/bcp.16342

Analysis of Adverse Reactions Associated with the Use of -Containing Herbal Products.

Woerdenbag HJ, Ursidae M, Ekhart C, Schmidt M, Vitalone A, van Hunsel FPAM — DOI: 10.3390/ph17111490

Brain organoid models for studying the function of iPSC-derived microglia in neurodegeneration and brain tumours.

Sabogal-Guaqueta AM, Mitchell-Garcia T, Hunneman J, Voshart D, Thiruvalluvan A, Foijer F, Kruyt F, Trombetta-Lima M, Eggen BJL, Boddeke E, Barazzuol L, Dolga AM — DOI: 10.1016/j.nbd.2024.106742

Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production.

Kiyuna LA, Krishnamurthy KA, Homan EB, Langelaar-Makkinje M, Gerding A, Bos T, Oosterhuis D, Overduin RJ, Schreuder AB, de Meijer VE, Olinga P, Derks TGJ, van Eunen K, Bakker BM, Oosterveer MH — DOI: 10.1038/s42003-024-07070-z

Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision-cut liver slices.

Luo K, Geng Y, Oosterhuis D, de Meijer VE, Olinga P — DOI: 10.14814/phy2.16136

Therapeutic effect of an inhaled levodopa dry powder formulation on off episodes in patients with Parkinson's disease.

de Jong L, Luinstra M, Aalbers AF, Wijma-Vos AJ, D'Angremont E, van der Meulen AAE, Rutgers AWF, Steenhuis L, Hagedoorn P, van Laar T, Frijlink HW — DOI: 10.1177/17562864241289207

The link between amyloid β and ferroptosis pathway in Alzheimer's disease progression.

Majerníková N, Marmolejo-Garza A, Salinas CS, Luu MDA, Zhang Y, Trombetta-Lima M, Tomin T, Birner-Gruenberger R, Lehtonen Š, Koistinaho J, Wolters JC, Ayton S, den Dunnen WFA, Dolga AM — DOI: 10.1038/s41419-024-07152-0

Real-Time Monitoring of Oxygen-Consumption Rate in Mouse Liver Slices Incubated in Organ-on-a-Chip Devices.

Karsten REH, Gier K, Mulder JSH, Grajewski M, Olinga P, Verpoorte E — DOI: 10.1021/acs.analchem.4c00355

Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral drug.

Heida R, Jacob Silva PH, Akkerman R, Moser J, de Vries-Idema J, Bornet A, Pawar S, Stellacci F, Frijlink HW, Huckriede ALW, Hinrichs WLJ — DOI: 10.1016/j.ejpb.2024.114507

Qualitative Interviews with Stakeholders in Herbal Pharmacovigilance and Recommendations for Best Practices to be Applied Worldwide.

Ekhart C, Wiarda SHP, van de Koppel S, Skalli S, Alghamdi W, Menniti-Ippolito F, Tangchitkhachon K, Mponda JS, Woerdenbag HJ, van Hunsel F — DOI: 10.1007/s40264-024-01480-y

The environmental burden of inhalation.

de Boer AH — DOI: 10.1016/j.ejps.2024.106893

Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing.

Janssen PHM, Fathollahi S, Dickhoff BHJ, Frijlink HW — DOI: 10.1080/17425247.2024.2384698

Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells.

Cattani-Cavalieri I, Trombetta-Lima M, Yan H, Manzano-Covarrubias AL, Baarsma HA, Oun A, van der Veen MM, Oosterhout E, Dolga AM, Ostrom RS, Valenca SS, Schmidt M — DOI: 10.3389/ftox.2024.1412864

Developing Medication Reviews to Improve the Aruban Healthcare System: A Mixed-Methods Pilot Study.

Copinga ML, Kok EA, van Dam AJJ, Wever A, Tromp A, Woerdenbag HJ — DOI: 10.3390/pharmacy12040108

Fibrogenesis in Human Mucosa and Muscularis Precision-Cut Intestinal Slices.

Biel C, Kastermans A, Heidema J, Pehrsson M, Henstra C, Mortensen J, Faber KN, Olinga P — DOI: 10.3390/cells13131084

Development and Implementation of an Ultraviolet-Dye-Based Qualification Procedure for Hand Washing and Disinfection to Improve Quality Assurance of Pharmacy Preparations and Compounding, Especially in Cleanrooms: A Pilot Study.

Knol CWJ, Stob PH, Woerdenbag HJ — DOI: 10.3390/pharmacy12030073

The Therapeutic Potential of Essential Oils in Managing Inflammatory Skin Conditions: A Scoping Review.

Dontje AEWK, Schuiling-Veninga CCM, van Hunsel FPAM, Ekhart C, Demirci F, Woerdenbag HJ — DOI: 10.3390/ph17050571

Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis.

Putri KSS, Adhyatmika A, Boorsma CE, Habibie H, Ruigrok MJR, Heukels P, Timens W, de Jager MH, Hinrichs WLJ, Olinga P, Melgert BN — DOI: 10.1007/s00408-024-00691-5

Variability in perfusion conditions and set-up parameters used in ex vivo human placenta models: A literature review.

Glättli SC, Elzinga FA, van der Bijl W, Leuvenink HGD, Prins JR, van Goor H, Gordijn SJ, Olinga P, Touw DJ, Mian P — DOI: 10.1016/j.placenta.2024.03.007

Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions.

Li M, Larsen FT, van den Heuvel MC, Gier K, Gorter AR, Oosterhuis D, Bijzet J, de Meijer VE, Ravnskjaer K, Nagelkerke A, Olinga P — DOI: 10.3390/nu16050626

Combinations of arginine and pullulan reveal the selective effect of stabilization mechanisms on different lyophilized proteins.

T T Nguyen K, Zillen D, Lasorsa A, van der Wel PCA, Frijlink HW, L J Hinrichs W — DOI: 10.1016/j.ijpharm.2024.123938

Batch vs. continuous direct compression - a comparison of material processability and final tablet quality.

Bekaert B, Janssen PHM, Fathollahi S, Vanderroost D, Roelofs T, Dickhoff BHJ, Vervaet C, Vanhoorne V — DOI: 10.1016/j.ijpx.2023.100226

Cellular senescence in brain aging and neurodegeneration.

Melo Dos Santos LS, Trombetta-Lima M, Eggen B, Demaria M — DOI: 10.1016/j.arr.2023.102141

Lipid profile in breast cancer: From signaling pathways to treatment strategies.

Taborda Ribas H, Sogayar MC, Dolga AM, Winnischofer SMB, Trombetta-Lima M — DOI: 10.1016/j.biochi.2023.11.008

Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module.

Bendixen SM, Jakobsgaard PR, Hansen D, Hejn KH, Terkelsen MK, Bjerre FA, Thulesen AP, Eriksen NG, Hallenborg P, Geng Y, Dam TV, Larsen FT, Wernberg CW, Vijayathurai J, Scott EAH, Marcher AB, Detlefsen S, Grøntved L, Dimke H, Berdeaux R, de Aguiar Vallim TQ, Olinga P, Lauridsen MM, Krag A, Blagoev B, Ravnskjaer K — DOI: 10.1016/j.jhep.2023.11.001

Matrix metalloproteinases in intestinal fibrosis.

Biel C, Faber KN, Bank RA, Olinga P — DOI: 10.1093/ecco-jcc/jjad178

Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model.

van Leeuwen LL, Ruigrok MJR, Kessler BM, Leuvenink HGD, Olinga P — DOI: 10.1111/bph.16220

Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease.

Otten AT, van der Meulen HH, Steenhuis M, Loeff FC, Touw DJ, Kosterink JGW, Frijlink HW, Rispens T, Dijkstra G, Visschedijk MC, Bourgonje AR — DOI: 10.1093/ibd/izad103

2023

Batch vs. continuous direct compression - a comparison of material processability and final tablet quality.

Bekaert B, Janssen PHM, Fathollahi S, Vanderroost D, Roelofs T, Dickhoff BHJ, Vervaet C, Vanhoorne V — DOI: 10.1016/j.ijpx.2023.100226

Cellular senescence in brain aging and neurodegeneration.

Melo Dos Santos LS, Trombetta-Lima M, Eggen B, Demaria M — DOI: 10.1016/j.arr.2023.102141

Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process.

Hebbink GA, Janssen PHM, Kok JH, Menarini L, Giatti F, Funaro C, Consoli SF, Dickhoff BHJ — DOI: 10.3390/pharmaceutics15112575

Lipid profile in breast cancer: From signaling pathways to treatment strategies.

Taborda Ribas H, Sogayar MC, Dolga AM, Winnischofer SMB, Trombetta-Lima M — DOI: 10.1016/j.biochi.2023.11.008

Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module.

Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: reasons to prioritize the pulmonary route of administration.

Heida R, Frijlink HW, Hinrichs WLJ — DOI: 10.1128/mbio.01295-23

Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings.

Nguyen KTT, Zillen D, van Heijningen FFM, van Bommel KJC, van Ee RJ, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics15092193

Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity.

Tjeerdsma AM, van Hunsel FPAM, van de Koppel S, Ekhart C, Vitalone A, Woerdenbag HJ — DOI: 10.3390/ph16081137

Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine.

Lee J, Beukema M, Zaplatynska OA, O'Mahony C, Hinrichs WLJ, Huckriede ALW, Bouwstra JA, van der Maaden K — DOI: 10.1039/d3bm00377a

Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model.

van Leeuwen LL, Ruigrok MJR, Kessler BM, Leuvenink HGD, Olinga P — DOI: 10.1111/bph.16220

Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges.

Luangmonkong T, Parichatikanond W, Olinga P — DOI: 10.1016/j.bcp.2023.115740

Hepatic stellate cells induce an inflammatory phenotype in Kupffer cells via the release of extracellular vesicles.

Geng Y, Wang J, Serna-Salas SA, Villanueva AH, Buist-Homan M, Arrese M, Olinga P, Blokzijl H, Moshage H — DOI: 10.1002/jcp.31086

Electronic monitoring with a digital smart spacer to support personalized inhaler use education in patients with asthma: The randomized controlled OUTERSPACE trial.

Dierick BJH, Achterbosch M, Eikholt AA, Been-Buck S, Klemmeier T, van de Hei SJ, Hagedoorn P, Kerstjens HAM, Kocks JWH, van Boven JFM — DOI: 10.1016/j.rmed.2023.107376

Human precision-cut cystic duct and gallbladder slices: a novel method for studying cholangiopathies.

Fridrichs J, Hamel B, Kelder W, van den Hoed E, van den Heuvel MC, Hulscher JBF, Olinga P — DOI: 10.3389/fped.2023.1058319

Performance Testing of a Homemade Aerosol Generator for Pulmonary Administration of Dry Powder Formulations to Mice.

Heida R, Hagedoorn P, van Meel MC, Prins JER, Simonis FS, Akkerman R, Huckriede ALW, Frijlink HW, de Boer AH, Hinrichs WLJ — DOI: 10.3390/pharmaceutics15071847

Placenta-on-a-Chip as an In Vitro Approach to Evaluate the Physiological and Structural Characteristics of the Human Placental Barrier upon Drug Exposure: A Systematic Review.

Elzinga FA, Khalili B, Touw DJ, Prins JR, Olinga P, Leuvenink HGD, van Goor H, Gordijn SJ, Nagelkerke A, Mian P — DOI: 10.3390/jcm12134315

Standardized Protocol for the Preparation of Precision-Cut Kidney Slices: A Translational Model of Renal Fibrosis.

Jensen MS, Merrild C, Nørregaard R, Olinga P, Mutsaers HAM — DOI: 10.1007/978-1-0716-3179-9_9

Nebulization of PEGylated recombinant human deoxyribonuclease I using vibrating membrane nebulizers: A technical feasibility study.

Mahri S, Wilms T, Hagedorm P, Guichard MJ, Vanvarenberg K, Dumoulin M, Frijlink H, Vanbever R — DOI: 10.1016/j.ejps.2023.106522

Capsules with Ileocolonic-Targeted Release of Vitamin B, B, and C (ColoVit) Intended for Optimization of Gut Health: Development and Validation of the Production Process.

Ahmed AA, Otten AT, Gareb B, Huijmans JE, Eissens AC, Rehman A, Dijkstra G, Kosterink JGW, Frijlink HW, Schellekens RCA — DOI: 10.3390/pharmaceutics15051354

Transcriptomic profiling of induced steatosis in human and mouse precision-cut liver slices.

Simon E, Motyka M, Prins GH, Li M, Rust W, Kauschke S, Viollet C, Olinga P, Oldenburger A — DOI: 10.1038/s41597-023-02220-0

Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment.

Woerdenbag HJ, Olinga P, Kok EA, Brugman DAP, van Ark UF, Ramcharan AS, Lebbink PW, Hoogwater FJH, Knapen DG, de Groot DJA, Nijkamp MW — DOI: 10.3390/cancers15072119

Development of an inhalable antiviral powder formulation against respiratory syncytial virus.

Heida R, Akkerman R, Jacob Silva PH, Lakerveld AJ, Ortiz D, Bigogno C, Gasbarri M, van Kasteren PB, Stellacci F, Frijlink HW, Huckriede ALW, Hinrichs WLJ — DOI: 10.1016/j.jconrel.2023.03.059

Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review.

Nugrahadi PP, Hinrichs WLJ, Frijlink HW, Schöneich C, Avanti C — DOI: 10.3390/pharmaceutics15030935

Effects of ileocolonic delivered vitamin B, B and C (ColoVit) or the Groningen anti-inflammatory diet on disease course and microbiome of patients with Crohn's disease (VITA-GrAID study): a protocol for a randomised and partially blinded trial.

Otten AT, Peters V, Barth I, Stevens CL, Bourgonje AR, Frijlink HW, Harmsen HJM, Rehman A, Campmans-Kuijpers MJE, Dijkstra G — DOI: 10.1136/bmjopen-2022-069654

Smart Specification Setting for Dry Powder Inhalation Carriers.

Janssen PHM, Bastiaansen M, Buijvoets LB, Frijlink HW — DOI: 10.1016/j.xphs.2023.02.018

A Single Injection with Sustained-Release Microspheres and a Prime-Boost Injection of Bovine Serum Albumin Elicit the Same IgG Antibody Response in Mice.

van der Kooij RS, Beukema M, Huckriede ALW, Zuidema J, Steendam R, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics15020676

Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion.

de Jong IEM, Bodewes SB, van Leeuwen OB, Oosterhuis D, Lantinga VA, Thorne AM, Lascaris B, van den Heuvel MC, Wells RG, Olinga P, de Meijer VE, Porte RJ — DOI: 10.1097/TP.0000000000004531

Hepatoprotective Efficacy of Cycloastragenol Alleviated the Progression of Liver Fibrosis in Carbon-Tetrachloride-Treated Mice.

Luangmonkong T, Puphancharoensuk P, Tongsongsang V, Olinga P, Parichatikanond W — DOI: 10.3390/biomedicines11010231

Differential effects of oleate on vascular endothelial and liver sinusoidal endothelial cells reveal its toxic features in vitro.

Geng Y, Arroyave-Ospina JC, Buist-Homan M, Plantinga J, Olinga P, Reijngoud DJ, Van Vilsteren FGI, Blokzijl H, Kamps JAAM, Moshage H — DOI: 10.1016/j.jnutbio.2022.109255

Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum).

Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ — DOI: 10.1002/ptr.7687

2022

Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum).

Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ — DOI: 10.1002/ptr.7687

RANKL confers protection against cell death in precision-cut lung slices.

Ruigrok MJR, Roest MAP, Frijlink HW, Olinga P, Hinrichs WLJ, Melgert BN — DOI: 10.3389/fphys.2022.1029697

Are inhaled mRNA vaccines safe and effective? A review of preclinical studies.

Jansen EM, Frijlink HW, Hinrichs WL, Ruigrok MJ — DOI: 10.1080/17425247.2022.2131767

Formulation of a 3D Printed Biopharmaceutical: The Development of an Alkaline Phosphatase Containing Tablet with Ileo-Colonic Release Profile to Treat Ulcerative Colitis.

Nguyen KTT, Heijningen FFM, Zillen D, van Bommel KJC, van Ee RJ, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics14102179

The impact of lactose type on disintegration: An integral study on porosity and polymorphism.

Janssen PHM, Berardi A, Kok JH, Thornton AW, Dickhoff BHJ — DOI: 10.1016/j.ejpb.2022.10.012

The Development and Implementation of Airflow Visualization Studies ("Smoke" Studies) as a Training Tool in Aseptic Hospital Compounding Facilities.

Borgonje PE, Wibier L, Noordman P, Woerdenbag HJ, Gareb B — DOI: 10.3390/pharmacy10050101

Dry powder inhalation, part 2: the present and future.

de Boer AH, Hagedoorn P, Grasmeijer F — DOI: 10.1080/17425247.2022.2112570

Dry powder inhalation, part 1: ancient history and precursors to modern dry powder inhalers.

de Boer AH, Hagedoorn P, Grasmeijer F — DOI: 10.1080/17425247.2022.2112568

Verteporfin ameliorates fibrotic aspects of Dupuytren's disease nodular fibroblasts irrespective the activation state of the cells.

Puerta Cavanzo N, Riesmeijer SA, Holt-Kedde IL, Werker PMN, Piersma B, Olinga P, Bank RA — DOI: 10.1038/s41598-022-18116-9

Pharmacology, particle deposition and drug administration techniques of intranasal corticosteroids for treating allergic rhinitis.

Rollema C, van Roon EN, van Boven JFM, Hagedoorn P, Klemmeier T, Kocks JH, Metting EI, Oude Elberink HNG, Peters TTA, San Giorgi MRM, de Vries TW — DOI: 10.1111/cea.14212

Digital spacer data driven COPD inhaler adherence education: The OUTERSPACE proof-of-concept study.

Dierick BJH, Been-Buck S, Klemmeier T, Hagedoorn P, van de Hei SJ, Kerstjens HAM, Kocks JWH, Zijp TR, Wessels AMA, Touw DJ, van Boven JFM — DOI: 10.1016/j.rmed.2022.106940

Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers.

de Reus YA, Hagedoorn P, Sturkenboom MGG, Grasmeijer F, Bolhuis MS, Sibum I, Kerstjens HAM, Frijlink HW, Akkerman OW — DOI: 10.1371/journal.pone.0272034

Assessing the Immunomodulatory Effect of Size on the Uptake and Immunogenicity of Influenza- and Hepatitis B Subunit Vaccines In Vitro.

Heida R, Born PA, Tapia-Calle G, Frijlink HW, Salvati A, Huckriede ALW, Hinrichs WLJ — DOI: 10.3390/ph15070887

Distinct responses between healthy and cirrhotic human livers upon lipopolysaccharide challenge: possible implications for acute-on-chronic liver failure.

Suriguga S, Li M, Luangmonkong T, Boersema M, de Jong KP, Oosterhuis D, Gorter AR, Beljaars L, Olinga P — DOI: 10.1152/ajpgi.00243.2021

Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis.

Karsten REH, Krijnen NJW, Maho W, Permentier H, Verpoorte E, Olinga P — DOI: 10.1007/s00204-022-03321-2

Turning green: the impact of changing to more eco-friendly respiratory healthcare - a carbon and cost analysis of Dutch prescription data.

Ten Have P, van Hal P, Wichers I, Kooistra J, Hagedoorn P, Brakema EA, Chavannes N, de Heer P, Ossebaard HC — DOI: 10.1136/bmjopen-2021-055546

Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised controlled OUTERSPACE trial.

Dierick BHJ, Achterbosch M, Been-Buck S, Klemmeier T, van de Hei SJ, Hagedoorn P, Kerstjens HAM, Kocks JWH, van Boven JFM — DOI: 10.1136/bmjopen-2021-059929

Analysis of Reports on Adverse Drug Reactions Related to Herbal Medicinal Products and Herbal Supplements in the Netherlands Received by the National Pharmacovigilance Centre Lareb.

van Hunsel FPAM, van der Kooi D, van de Koppel S, Kroes BH, Woerdenbag HJ — DOI: 10.1007/s40264-022-01180-5

The effect of excipient particle size on the reduction of compactibility after roller compaction.

Janssen PHM, Jaspers M, Meier R, Roelofs TP, Dickhoff BHJ — DOI: 10.1016/j.ijpx.2022.100117

Extending the viability of human precision-cut intestinal slice model for drug metabolism studies.

Biel C, Martinec O, Sibering B, van Summeren K, Wessels AMA, Touw DJ, de Jong KP, de Meijer VE, Faber KN, Klooster JPT, de Graaf IAM, Olinga P — DOI: 10.1007/s00204-022-03295-1

Performance of Tablet Splitters, Crushers, and Grinders in Relation to Personalised Medication with Tablets.

Woerdenbag HJ, Visser JC, Leferink Op Reinink MPAM, van Orsoy RR, Eissens AC, Hagedoorn P, Dijkstra H, Allersma DP, Ng SW, Smeets OSNM, Frijlink HW — DOI: 10.3390/pharmaceutics14020320

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays.

Tian Y, Lee J, van der Maaden K, Bhide Y, de Vries-Idema JJ, Akkerman R, O'Mahony C, Jiskoot W, Frijlink HW, Huckriede ALW, Hinrichs WLJ, Bouwstra JA, Beukema M — DOI: 10.1016/j.xphs.2022.01.033

Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants: Supplementing Perfusion Solutions With Anti-fibrotic Drugs.

van Leeuwen LL, Leuvenink HGD, Olinga P, Ruigrok MJR — DOI: 10.3389/fmed.2021.806774

Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ.

Adhyatmika A, Putri KSS, Gore E, Mangnus KA, Reker-Smit C, Schuppan D, Beljaars L, Olinga P, Melgert BN — DOI: 10.33594/000000492

An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery.

van der Kooij RS, Steendam R, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.ejpb.2021.11.007

New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4.

Weder B, Schefer F, van Haaften WT, Patsenker E, Stickel F, Mueller S, Hutter S, Schuler C, Baebler K, Wang Y, Mamie C, Dijkstra G, de Vallière C, Imenez Silva PH, Wagner CA, Frey-Wagner I, Ruiz PA, Seuwen K, Rogler G, Hausmann M — DOI: 10.1093/ibd/izab140

Inhaled vaccine delivery in the combat against respiratory viruses: a 2021 overview of recent developments and implications for COVID-19.

Heida R, Hinrichs WL, Frijlink HW — DOI: 10.1080/14760584.2021.1903878

Science- and risk-based strategy to qualify prefillable autoclavable syringes as primary packaging material.

Larmené-Beld K, Wijnsma R, Kuiper A, van Berkel S, Robben H, Taxis K, Frijlink H — DOI: 10.1136/ejhpharm-2020-002333

2021

Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants: Supplementing Perfusion Solutions With Anti-fibrotic Drugs.

van Leeuwen LL, Leuvenink HGD, Olinga P, Ruigrok MJR — DOI: 10.3389/fmed.2021.806774

The Effects of Butyrate on Induced Metabolic-Associated Fatty Liver Disease in Precision-Cut Liver Slices.

Prins GH, Rios-Morales M, Gerding A, Reijngoud DJ, Olinga P, Bakker BM — DOI: 10.3390/nu13124203

Formulation and In Vitro Evaluation of Pellets Containing Sulfasalazine and Caffeine to Verify Ileo-Colonic Drug Delivery.

Broesder A, Bircan SY, de Waard AB, Eissens AC, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics13121985

An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery.

van der Kooij RS, Steendam R, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.ejpb.2021.11.007

Microfluidic Production of Polymeric Core-Shell Microspheres for the Delayed Pulsatile Release of Bovine Serum Albumin as a Model Antigen.

van der Kooij RS, Steendam R, Zuidema J, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics13111854

Editorial: Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets.

Mutsaers HAM, Nørregaard R, Olinga P — DOI: 10.3389/fmed.2021.793507

The gastrointestinal microbiota in colorectal cancer cell migration and invasion.

Henstra C, van Praagh J, Olinga P, Nagelkerke A — DOI: 10.1007/s10585-021-10130-x

Hepatic Steatosis Contributes to the Development of Muscle Atrophy Inter-Organ Crosstalk.

Pasmans K, Adriaens ME, Olinga P, Langen R, Rensen SS, Schaap FG, Olde Damink SWM, Caiment F, van Loon LJC, Blaak EE, Meex RCR — DOI: 10.3389/fendo.2021.733625

Local Inhibition of Indoleamine 2,3-Dioxygenase Mitigates Renal Fibrosis.

Jensen CG, Jensen MS, Tingskov SJ, Olinga P, Nørregaard R, Mutsaers HAM — DOI: 10.3390/biomedicines9080856

An Organogold Compound as Potential Antimicrobial Agent against Drug-Resistant Bacteria: Initial Mechanistic Insights.

Chakraborty P, Oosterhuis D, Bonsignore R, Casini A, Olinga P, Scheffers DJ — DOI: 10.1002/cmdc.202100342

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices.

Martinec O, Biel C, de Graaf IAM, Huliciak M, de Jong KP, Staud F, Cecka F, Olinga P, Vokral I, Cerveny L — DOI: 10.3389/fphar.2021.684156

Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction.

Majorova D, Atkins E, Martineau H, Vokral I, Oosterhuis D, Olinga P, Wren B, Cuccui J, Werling D — DOI: 10.3389/fvets.2021.686088

Educational Video Improves Knowledge about Outpatients' Usage of Antibiotics in Two Public Hospitals in Indonesia.

Herawati F, Yulia R, Arifin B, Frasetyo I, Setiasih , Woerdenbag HJ, Avanti C, Andrajati R — DOI: 10.3390/antibiotics10050606

Ileo-Colon Targeting of the Poorly Water-Soluble Drug Celecoxib Using a pH-Dependent Coating in Combination with Self-Emulsifying Drug Delivery or Solid Dispersion Systems.

Broesder A, Berends JME, Scheepers SM, Nguyen DN, Frijlink HW, Hinrichs WLJ — DOI: 10.3390/pharmaceutics13050731

Isocratic high-performance liquid chromatography (HPLC) for simultaneous quantification of curcumin and piperine in a microparticle formulation containing and .

Setyaningsih D, Santoso YA, Hartini YS, Murti YB, Hinrichs WLJ, Patramurti C — DOI: 10.1016/j.heliyon.2021.e06541

Biofilm Formation Assay on Essential Oil Coated Silicone Rubber.

Sahal G, Woerdenbag HJ, Hinrichs WLJ, Visser A, van der Mei HC, Bilkay IS — DOI: 10.21769/BioProtoc.3941

Colorectal anastomotic leak: transcriptomic profile analysis.

van Praagh JB, de Wit JG, Olinga P, de Haan JJ, Nagengast WB, Fehrmann RSN, Havenga K — DOI: 10.1093/bjs/znaa066

Inhaled vaccine delivery in the combat against respiratory viruses: a 2021 overview of recent developments and implications for COVID-19.

Heida R, Hinrichs WL, Frijlink HW — DOI: 10.1080/14760584.2021.1903878

Legislation and current developments in adverse drug reaction reporting in Mongolia: how far are we?

Zulzaga Z, Myagmarsuren E, Woerdenbag HJ, van Puijenbroek EP — DOI: 10.1186/s40545-021-00298-8

Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis?

Ruigrok MJR, El Amasi KEM, Leeming DJ, Sand JMB, Frijlink HW, Hinrichs WLJ, Olinga P — DOI: 10.3389/fmed.2021.607962

Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions.

Ruigrok MJR, Frijlink HW, Melgert BN, Olinga P, Hinrichs WLJ — DOI: 10.1016/j.omtm.2021.01.003

Nanoparticle-induced inflammation and fibrosis in ex vivo murine precision-cut liver slices and effects of nanoparticle exposure conditions.

Bartucci R, van der Meer AZ, Boersma YL, Olinga P, Salvati A — DOI: 10.1007/s00204-021-02992-7

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo.

Kocabiyik O, Cagno V, Silva PJ, Zhu Y, Sedano L, Bhide Y, Mettier J, Medaglia C, Da Costa B, Constant S, Huang S, Kaiser L, Hinrichs WLJ, Huckriede A, Le Goffic R, Tapparel C, Stellacci F — DOI: 10.1002/advs.202001012

Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited.

Puerta Cavanzo N, Bigaeva E, Boersema M, Olinga P, Bank RA — DOI: 10.3389/fmed.2020.615774

Science- and risk-based strategy to qualify prefillable autoclavable syringes as primary packaging material.

Larmené-Beld K, Wijnsma R, Kuiper A, van Berkel S, Robben H, Taxis K, Frijlink H — DOI: 10.1136/ejhpharm-2020-002333

Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition.

Smith-Cortinez N, Fagundes RR, Gomez V, Kong D, de Waart DR, Heegsma J, Sydor S, Olinga P, de Meijer VE, Taylor CT, Bank R, Paulusma CC, Faber KN — DOI: 10.1096/fj.202001564RR

The pharmacokinetics of antibiotics in cystic fibrosis.

Akkerman-Nijland AM, Akkerman OW, Grasmeijer F, Hagedoorn P, Frijlink HW, Rottier BL, Koppelman GH, Touw DJ — DOI: 10.1080/17425255.2021.1836157

Advances in the development of entry inhibitors for sialic-acid-targeting viruses.

Heida R, Bhide YC, Gasbarri M, Kocabiyik Ö, Stellacci F, Huckriede ALW, Hinrichs WLJ, Frijlink HW — DOI: 10.1016/j.drudis.2020.10.009

The Citrullinated and MMP-degraded Vimentin Biomarker (VICM) Predicts Early Response to Anti-TNFα Treatment in Crohn's Disease.

Mortensen JH, van Haaften WT, Karsdal MA, Bay-Jensen AC, Olinga P, Grønbæk H, Hvas CL, Manon-Jensen T, Dijkstra G, Dige A — DOI: 10.1097/MCG.0000000000001341

2020

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo.

Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited.

Puerta Cavanzo N, Bigaeva E, Boersema M, Olinga P, Bank RA — DOI: 10.3389/fmed.2020.615774

Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature.

Nomden M, Beljaars L, Verkade HJ, Hulscher JBF, Olinga P — DOI: 10.3389/fmed.2020.617261

Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition.

Smith-Cortinez N, Fagundes RR, Gomez V, Kong D, de Waart DR, Heegsma J, Sydor S, Olinga P, de Meijer VE, Taylor CT, Bank R, Paulusma CC, Faber KN — DOI: 10.1096/fj.202001564RR

The pharmacokinetics of antibiotics in cystic fibrosis.

Akkerman-Nijland AM, Akkerman OW, Grasmeijer F, Hagedoorn P, Frijlink HW, Rottier BL, Koppelman GH, Touw DJ — DOI: 10.1080/17425255.2021.1836157

Advances in the development of entry inhibitors for sialic-acid-targeting viruses.

Heida R, Bhide YC, Gasbarri M, Kocabiyik Ö, Stellacci F, Huckriede ALW, Hinrichs WLJ, Frijlink HW — DOI: 10.1016/j.drudis.2020.10.009

Serological Biomarkers of Tissue Turnover Identify Responders to Anti-TNF Therapy in Crohn's Disease: A Pilot Study.

van Haaften WT, Mortensen JH, Dige AK, Grønbæk H, Hvas CL, Bay-Jensen AC, Karsdal MA, Olinga P, Manon-Jensen T, Dijkstra G — DOI: 10.14309/ctg.0000000000000217

Colistin dry powder inhalation with the Twincer™: An effective and more patient friendly alternative to nebulization.

Akkerman-Nijland AM, Grasmeijer F, Kerstjens HAM, Frijlink HW, van der Vaart H, Vonk JM, Hagedoorn P, Rottier BL, Koppelman GH, Akkerman OW — DOI: 10.1371/journal.pone.0239658

Intestinal stenosis in Crohn's disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets.

van Haaften WT, Blokzijl T, Hofker HS, Olinga P, Dijkstra G, Bank RA, Boersema M — DOI: 10.1177/1756284820952578

Prefilled Cyclic Olefin Sterilized Syringes of Norepinephrine Injection Solution Do Not Need to Be Stabilized by Antioxidants.

Larmené-Beld KHM, van Berkel S, Wijnsma R, Taxis K, Frijlink HW — DOI: 10.1208/s12249-020-01784-z

Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices.

Biel C, Bigaeva E, Hesse M, Bomers JJM, van Summeren K, Teunis MAT, Vaessen S, Ten Klooster JP, Olinga P — DOI: 10.1016/j.tiv.2020.104974

Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops High Dose Dry Powder Inhalation Device While Maintaining Dispersibility.

Sibum I, Hagedoorn P, Botterman CO, Frijlink HW, Grasmeijer F — DOI: 10.3390/pharmaceutics12070645

Host microbiota dictates the proinflammatory impact of LPS in the murine liver.

Suriguga S, Luangmonkong T, Mutsaers HAM, Groothuis GMM, Olinga P — DOI: 10.1016/j.tiv.2020.104920

pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients.

Broesder A, Kosta AMAC, Woerdenbag HJ, Nguyen DN, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.drudis.2020.06.012

pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems.

Broesder A, Woerdenbag HJ, Prins GH, Nguyen DN, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.drudis.2020.06.011

Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease.

Gareb B, Otten AT, Frijlink HW, Dijkstra G, Kosterink JGW — DOI: 10.3390/pharmaceutics12060539

Comparative study of nanoparticle uptake and impact in murine lung, liver and kidney tissue slices.

Bartucci R, Paramanandana A, Boersma YL, Olinga P, Salvati A — DOI: 10.1080/17435390.2020.1771785

Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver.

Adhyatmika A, Beljaars L, Putri KSS, Habibie H, Boorsma CE, Reker-Smit C, Luangmonkong T, Guney B, Haak A, Mangnus KA, Post E, Poelstra K, Ravnskjaer K, Olinga P, Melgert BN — DOI: 10.3390/pharmaceutics12050471

Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis.

Bigaeva E, Puerta Cavanzo N, Stribos EGD, de Jong AJ, Biel C, Mutsaers HAM, Jensen MS, Nørregaard R, Leliveld AM, de Jong IJ, Hillebrands JL, van Goor H, Boersema M, Bank RA, Olinga P — DOI: 10.3390/pharmaceutics12050459

Potential implications of COVID-19 in non-alcoholic fatty liver disease.

Prins GH, Olinga P — DOI: 10.1111/liv.14484

Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: a single oral dose study before and after surgery.

Yska JP, Wanders JTM, Odigie B, Apers JA, Emous M, Totté ERE, Boerma EC, Ubels FL, Woerdenbag HJ, Frijlink HW, Wilffert B, van Roon EN — DOI: 10.1136/ejhpharm-2018-001804

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis.

van Dijk F, Hazelhoff CM, Post E, Prins GGH, Rombouts K, Poelstra K, Olinga P, Beljaars L — DOI: 10.3390/pharmaceutics12030278

Development of an Orodispersible Film Containing Stabilized Influenza Vaccine.

Tian Y, Bhide YC, Woerdenbag HJ, Huckriede ALW, Frijlink HW, Hinrichs WLJ, Visser JC — DOI: 10.3390/pharmaceutics12030245

Reply.

Hagedoorn P, Bawary W, Frijlink HW, Grasmeijer F — DOI: 10.1016/j.jaip.2019.11.023

The Effect of Food on the Pharmacokinetics of Buspirone After Single Administration of a Sublingual Testosterone and Oral Buspirone Combination Tablet in Healthy Female Subjects.

Gerritsen J, Bloemers J, van Rooij K, de Leede L, van der Geest R, Frijlink HW, Koppeschaar HPF, Olivier B, Tuiten A — DOI: 10.1016/j.esxm.2020.01.005

A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films.

Visser JC, Wibier L, Kiefer O, Orlu M, Breitkreutz J, Woerdenbag HJ, Taxis K — DOI: 10.3390/pharmaceutics12020164

Time-Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision-Cut Liver Slices.

Bartucci R, Åberg C, Melgert BN, Boersma YL, Olinga P, Salvati A — DOI: 10.1002/smll.201906523

Orodispersible films as a personalized dosage form for nursing home residents, an exploratory study.

Visser JC, Wibier L, Mekhaeil M, Woerdenbag HJ, Taxis K — DOI: 10.1007/s11096-020-00990-w

Eradication of in cystic fibrosis patients with inhalation of dry powder tobramycin.

Akkerman-Nijland AM, Yousofi M, Rottier BL, Van der Vaart H, Burgerhof JGM, Frijlink HW, Touw DJ, Koppelman GH, Akkerman OW — DOI: 10.1177/1753466620905279

Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs.

Iswandana R, Pham BT, Suriguga S, Luangmonkong T, van Wijk LA, Jansen YJM, Oosterhuis D, Mutsaers HAM, Olinga P — DOI: 10.1093/ibd/izz329

Interview-based cross-sectional needs assessment to advance the implementation of an effective antibiotic stewardship program in Indonesian hospitals.

Herawati F, Ananta SC, Parwitha IAA, Ressandy SS, Rahmatin NL, Rachmadini NA, Tangalobo VA, Setiasih , Yulia R, Hak E, Woerdenbag HJ, Avanti C — DOI: 10.1016/j.hpopen.2019.100002

Investigating fibrosis and inflammation in an ex vivo NASH murine model.

Gore E, Bigaeva E, Oldenburger A, Jansen YJM, Schuppan D, Boersema M, Rippmann JF, Broermann A, Olinga P — DOI: 10.1152/ajpgi.00209.2019

Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies.

Busscher HJ, Woudstra W, van Kooten TG, Jutte P, Shi L, Liu J, Hinrichs WLJ, Frijlink HW, Shi R, Liu J, Parvizi J, Kates S, Rotello VM, Schaer TP, Williams D, Grainger DW, van der Mei HC — DOI: 10.1016/j.biomaterials.2019.119737

Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis.

Bigaeva E, Stribos EGD, Mutsaers HAM, Piersma B, Leliveld AM, de Jong IJ, Bank RA, Seelen MA, van Goor H, Wollin L, Olinga P, Boersema M — DOI: 10.1152/ajprenal.00108.2019

Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices.

Bigaeva E, Gore E, Mutsaers HAM, Oosterhuis D, Kim YO, Schuppan D, Bank RA, Boersema M, Olinga P — DOI: 10.1016/j.bbadis.2019.165582

Inhomogeneous Distribution of Components in Solid Protein Pharmaceuticals: Origins, Consequences, Analysis, and Resolutions.

Nguyen KTT, Frijlink HW, Hinrichs WLJ — DOI: 10.1016/j.xphs.2019.10.010

A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers.

Hagedoorn P, Bawary W, Frijlink HW, Grasmeijer F — DOI: 10.1016/j.jaip.2019.09.021

Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study.

Sahal G, Woerdenbag HJ, Hinrichs WLJ, Visser A, Tepper PG, Quax WJ, van der Mei HC, Bilkay IS — DOI: 10.1016/j.jep.2019.112188

Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome.

Weerts ZZRM, Masclee AAM, Witteman BJM, Clemens CHM, Winkens B, Brouwers JRBJ, Frijlink HW, Muris JWM, De Wit NJ, Essers BAB, Tack J, Snijkers JTW, Bours AMH, de Ruiter-van der Ploeg AS, Jonkers DMAE, Keszthelyi D — DOI: 10.1053/j.gastro.2019.08.026

Nasal gene expression changes with inhaled corticosteroid treatment in asthma.

Boudewijn IM, Lan A, Faiz A, Cox CA, Brouwer S, Schokker S, Vroegop SJ, Nawijn MC, Woodruff PG, Christenson SA, Hagedoorn P, Frijlink HW, Choy DF, Brouwer U, Wisman M, Postma DS, Fingleton J, Beasley R, van den Berge M, Guryev V — DOI: 10.1111/all.13952