Advanced Human Models
The Matrix Organoid Lab is led by Dr Marina Trombetta-Lima and explores microenvironment engineering as a new conceptual and technological framework to decode aging and different human diseases.
We work with the postulate that aging and metabolic disorders do not arise from isolated organ dysfunction, but from disrupted inter-organ communication embedded within evolving tissue microenvironments. To test this paradigm, we develop next-generation human organoid-based platforms that reconstruct endocrine, inflammatory, and metabolic signaling across organs. Our disease models focus on mechanistic reconstruction allowing precision intervention.
Core pillars:
- Microenvironment engineering as a unifying disease principle
- Human multi-organ organoid systems with controlled inter-organ signaling
- Systems-level dissection of endocrine–immune–neural crosstalk
- Translation toward stratified, mechanism-based therapeutic strategies